Téléchargez le livre : Insulin Resistance and Cancer

Insulin Resistance and Cancer

Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications de

Éditeur :

Springer


Collection :

Energy Balance and Cancer

Paru le : 2011-08-19

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Description
This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.
Pages
300 pages
Collection
Energy Balance and Cancer
Parution
2011-08-19
Marque
Springer
EAN papier
9781441999108
EAN PDF
9781441999115
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
30
Taille du fichier
3901 Ko
Prix
147,69 €
EAN EPUB
9781441999115
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
30
Taille du fichier
1147 Ko
Prix
147,69 €

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