Téléchargez le livre : Filaggrin

Filaggrin

Basic Science, Epidemiology, Clinical Aspects and Management de

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Éditeur :

Springer


Paru le : 2014-05-27

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Description
Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.
Pages
373 pages
Collection
n.c
Parution
2014-05-27
Marque
Springer
EAN papier
9783642543784
EAN EPUB
9783642543791
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
37
Taille du fichier
4884 Ko
Prix
94,94 €

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