Téléchargez le livre : Proteopathic Seeds and Neurodegenerative Diseases

Proteopathic Seeds and Neurodegenerative Diseases

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Éditeur :

Springer


Collection :

Research and Perspectives in Alzheimer's Disease

Paru le : 2013-03-27

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Description
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ?
Pages
156 pages
Collection
Research and Perspectives in Alzheimer's Disease
Parution
2013-03-27
Marque
Springer
EAN papier
9783642354908
EAN EPUB
9783642354915
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
15
Taille du fichier
2458 Ko
Prix
147,69 €

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