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Description

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. 
Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
Pages
885 pages
Collection
Advances in Experimental Medicine and Biology
Parution
2020-04-09
Marque
Springer
EAN papier
9783030345204
EAN PDF
9783030345211
Informations sur l'ebook
Nombre pages copiables
8
Nombre pages imprimables
88
Taille du fichier
21166 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
211,99 €
EAN EPUB
9783030345211
Informations sur l'ebook
Nombre pages copiables
8
Nombre pages imprimables
88
Taille du fichier
58860 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
211,99 €

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