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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

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Éditeur :

Springer


Collection :

Lecture Notes in Computational Science and Engineering

Paru le : 2016-04-19

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Description

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs.  Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.
Pages
261 pages
Collection
Lecture Notes in Computational Science and Engineering
Parution
2016-04-19
Marque
Springer
EAN papier
9783319300290
EAN PDF
9783319300306
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
26
Taille du fichier
7404 Ko
Prix
0,00 €
EAN EPUB
9783319300306
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
26
Taille du fichier
3912 Ko
Prix
0,00 €

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