Téléchargez le livre : Amorphous Solid Dispersions

Amorphous Solid Dispersions

Theory and Practice

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Éditeur :

Springer


Collection :

Advances in Delivery Science and Technology

Paru le : 2014-11-21



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Description

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems.
Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.
Pages
699 pages
Collection
Advances in Delivery Science and Technology
Parution
2014-11-21
Marque
Springer
EAN papier
9781493915972
EAN EPUB
9781493915989
Informations sur l'ebook
Nombre pages copiables
6
Nombre pages imprimables
69
Taille du fichier
10291 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
252,14 €

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